Global application Settings can help you use Kameleo faster.
This will help you filter Base Profiles faster and set up profiles easier by providing default for all the values. It worth checking all the options.
There are a couple of other settings that can be reached here:
Autosave on close
If this is enabled, when you close the browser the profile will be saved (updated) if it was already saved to a .kameleo file.
Auto show external
When you start a mobile profile or a profile with the External Spoofing Engine, the connection info dialog will appear. You can disable this here.